Journal
INTERNATIONAL JOURNAL OF NANOMEDICINE
Volume 13, Issue -, Pages 7473-7490Publisher
DOVE MEDICAL PRESS LTD
DOI: 10.2147/IJN.S181343
Keywords
selenium; selenium nanoparticles; nanomedicine; biomedical applications; drug delivery; oncotherapy; diabetes
Funding
- National Natural Science Foundation of China [81673604]
- Fundamental Research Funds for the Central Universities [21617473, 21615473]
- Scientific Research Foundation of the First Affiliated Hospital of Jinan University, China [2015210, 2017305]
- Medical Science and Technology Foundation of Guangdong Province [A2018313, A2016040]
- Traditional Chinese Medicine Administration Foundation of Guangdong Province [20161072]
- Natural Science Foundation of Guangdong Province [2016ZC0042, 2016ZC0048]
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Selenium as a biologically active element lends much support to health maintenance and disease prevention. It is now presenting pleiotropic effects on therapy and drug delivery. In this study, a profiling on the physiological functions, therapeutic significances, clinical/preclinical performances, and biomedical and drug delivery applications of selenium in different modalities was carried out. Major interests focused on selenium-based nanomedicines in confronting various diseases pertaining to selenium or not, especially in antitumor and antidiabetes. Furthermore, the article exclusively discusses selenium nanoparticles featured by ameliorative functions with emphasis on their applications in medical practice and drug delivery. The state-of-the-art in medical discovery as well as research and development on selenium and nano-selenium is discussed in this review.
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