Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 20, Issue 1, Pages -Publisher
MDPI
DOI: 10.3390/ijms20010074
Keywords
DNA repair; double strand break repair; exonuclease 1; EXO1; mismatch repair; MMR; NER; nucleotide excision repair; strand displacements; TLS; translesion DNA synthesis
Funding
- Arvid Nilssons Fond
- Fabrikant Einer Willumsens Mindelegat
- Oda og Hans Svenningsens Fond
- Harboe fonden [15292]
- Vissing fonden [54622]
- German Research Foundation Forschungsstipendium [BA 6276/1-1]
- Danish Council for Independent Research [DFF-7016-00230]
- Danish Cancer Society [R167-A11015-17-S2]
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Human exonuclease 1 (EXO1), a 53 exonuclease, contributes to the regulation of the cell cycle checkpoints, replication fork maintenance, and post replicative DNA repair pathways. These processes are required for the resolution of stalled or blocked DNA replication that can lead to replication stress and potential collapse of the replication fork. Failure to restart the DNA replication process can result in double-strand breaks, cell-cycle arrest, cell death, or cellular transformation. In this review, we summarize the involvement of EXO1 in the replication, DNA repair pathways, cell cycle checkpoints, and the link between EXO1 and cancer.
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