Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 19, Issue 12, Pages -Publisher
MDPI
DOI: 10.3390/ijms19123928
Keywords
TGF superfamily; TGF signaling; B cell; immune homeostasis; tolerance; autoimmunity
Funding
- Spanish Ministerio de Economia y Competitividad [SAF2017-82905-R]
- European Regional Development Fund
Ask authors/readers for more resources
The TGF superfamily is composed of more than 33 growth and differentiation factors, including TGF1, 2, 3, BMPs, GDFs, nodal-related proteins, and activins. These members usually exert pleiotropic actions on several tissues and control multiple cellular processes, such as cell growth, cell survival, cell migration, cell fate specification, and differentiation, both during embryonic development and postnatal life. Although the effects of these factors on immune responses were elucidated long ago, most studies have been focused on the actions of TGFs on T cells, as major regulators of adaptive immunity. In this review, we discuss new findings about the involvement of TGF superfamily members in the control of B cell development and function. Moreover, the potential contribution of TGF signaling to control B cell-mediated autoimmune diseases and its utility in the design of new therapies are also discussed.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available