Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 19, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/ijms19113630
Keywords
FXR; PXR; CAR; bile acids; xenobiotics; metabolism and transport; cancer; drug resistance
Funding
- French National Center for Scientific Research (CNRS)
- Clermont Auvergne University (UCA)
- French National Institute of Health and Medical Research (INSERM)
- French League Against Cancer (Puy-de-Dome committee)
- ARC Foundation [R16142CC]
- Auvergne Young Investigator program [R12087CC]
- InCa/INSERM Cancer-Environment research program [C14012CS]
- French Government IDEX-ISITE initiative [CAP 20-25 (16-IDEX-0001)]
- French Foundation for Medical Research (FRM)
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Structural and functional studies have provided numerous insights over the past years on how members of the nuclear hormone receptor superfamily tightly regulate the expression of drug-metabolizing enzymes and transporters. Besides the role of the farnesoid X receptor (FXR) in the transcriptional control of bile acid transport and metabolism, this review provides an overview on how this metabolic sensor prevents the accumulation of toxic byproducts derived from endogenous metabolites, as well as of exogenous chemicals, in coordination with the pregnane X receptor (PXR) and the constitutive androstane receptor (CAR). Decrypting this network should provide cues to better understand how these metabolic nuclear receptors participate in physiologic and pathologic processes with potential validation as therapeutic targets in human disabilities and cancers.
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