Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 19, Issue 11, Pages -Publisher
MDPI
DOI: 10.3390/ijms19113611
Keywords
idiopathic pulmonary fibrosis; non-small cell lung cancer; transforming growth factor-; extracellular matrix; tumor microenvironment; usual interstitial pneumonia
Funding
- Takeda Science Foundation
- Uehara Memorial Foundation Research Fellowship
- JSPS KAKENHI [18K08170, 16H02653]
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Idiopathic pulmonary fibrosis (IPF) is a progressive fibrotic lung disease of unknown etiology and dismal prognosis. IPF patients are known to have an increased risk of lung cancer and careful decision-making is required for the treatment of lung cancer associated with IPF. Transforming growth factor (TGF)- signaling plays a central role in tissue fibrosis and tumorigenesis. TGF--mediated pathological changes that occur in IPF lung tissue may promote the process of field cancerization and provide the microenvironment favorable to cancer initiation and progression. This review summarizes the current knowledge related to IPF pathogenesis and explores the molecular mechanisms that underlie the occurrence of lung cancer in the background of IPF, with an emphasis on the multifaceted effects of TGF- signaling.
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