Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 19, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/ijms19103041
Keywords
Acinetobacter baumannii; multidrug-resistant; antimicrobial peptide; antibiofilm activity; physiological salt
Funding
- National Research Foundation of Korea (NRF) - Korean Government [2016R1A2A1A05005440, NRF-2017M3A9E4077206]
- Global Research Laboratory (GRL) [NRF-2014K1A1A2064460]
- Institute for Information & communications Technology Promotion (IITP) - Korea government (MSIT) [2017-0-01714]
- National Research Foundation of Korea [2016R1A2A1A05005440] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
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Antimicrobial peptides (AMPs) are promising therapeutic agents for treating antibiotic-resistant bacterial infections. Previous studies showed that magainin 2 (isolated from African clawed fogs Xenopus laevis) has antimicrobial activity against gram-positive and gram-negative bacteria. The present study was conducted to investigate the antibacterial activity of magainin 2 against Acinetobacter baumannii. Magainin 2 showed excellent antibacterial activity against A. baumannii strains and high stability at physiological salt concentrations. This peptide was not cytotoxic towards HaCaT cells and showed no hemolytic activity. Biofilm inhibition and elimination were significantly induced in all A. baumannii strains exposed to magainin 2. We confirmed the mechanism of magainin 2 on the bacterial outer and inner membranes. Collectively, these results suggest that magainin 2 is an effective antimicrobial and antibiofilm agent against A. baumannii strains.
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