Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 19, Issue 10, Pages -Publisher
MDPI
DOI: 10.3390/ijms19103103
Keywords
liver fibrosis; Wnt; -catenin; PRI-724
Funding
- Japan Agency for Medical Research and Development (AMED) [15fk0210025h003, 16lm0103008j0005, 16im0210105h0001]
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Cirrhosis is a form of liver fibrosis resulting from chronic hepatitis and caused by various liver diseases, including viral hepatitis, alcoholic liver damage, nonalcoholic steatohepatitis, and autoimmune liver disease. Cirrhosis leads to various complications, resulting in poor prognoses; therefore, it is important to develop novel antifibrotic therapies to counter liver cirrhosis. Wnt/-catenin signaling is associated with the development of tissue fibrosis, making it a major therapeutic target for treating liver fibrosis. In this review, we present recent insights into the correlation between Wnt/-catenin signaling and liver fibrosis and discuss the antifibrotic effects of the cAMP-response element binding protein/-catenin inhibitor PRI-724.
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