Journal
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES
Volume 20, Issue 2, Pages -Publisher
MDPI
DOI: 10.3390/ijms20020317
Keywords
natural killer cell line; NK-92; chimeric antigen receptor; immunotherapy; tumor
Funding
- National Natural Science Foundation of China [81371669]
- Project of Science and Technology of Quanzhou of China [2016Z006]
- Major project of University and Industry Cooperation in Fujian Province of China [2018Y4009]
- Subsidized Project for Cultivating Postgraduates' Innovative Ability in Scientific Research of Huaqiao University [1601116007]
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Natural killer (NK) cells are innate immune cells that can be activated rapidly to target abnormal and virus-infected cells without prior sensitization. With significant advancements in cell biology technologies, many NK cell lines have been established. Among these cell lines, NK-92 cells are not only the most widely used but have also been approved for clinical applications. Additionally, chimeric antigen receptor-modified NK-92 cells (CAR-NK-92 cells) have shown strong antitumor effects. In this review, we summarize established human NK cell lines and their biological characteristics, and highlight the applications of NK-92 cells and CAR-NK-92 cells in tumor immunotherapy.
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