Journal
INTERNATIONAL JOURNAL OF MEDICAL MICROBIOLOGY
Volume 309, Issue 2, Pages 143-150Publisher
ELSEVIER GMBH
DOI: 10.1016/j.ijmm.2019.01.001
Keywords
mig-14; S. Typhi; Antimicrobial resistance; ompF; ompC; Biofilm
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Funding
- National Natural Foundation of China [31000046]
- Professional Research Foundation for Advanced Talents of Jiangsu University [11JDG063]
- China Postdoctoral Science Foundation [2015M571702]
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Mig-14 is essential for Salmonella enterica serovar Typhimurium (S. Typhimurium) resistance to antimicrobial peptides, including polymyxin B (PB). However, the molecular mechanism is as yet unknown. In this study, we demonstrated that mig-14 also played a crucial role in Salmonella enterica serovar Typhi (S. Typhi) resistance to PB. A series of genes associated with drug-resistance controlled by Mig-14 were identified in the presence of PB. Among which, ompF and ompC were up-regulated 8 and 6 folds in mig-14 mutant (Delta mig-14) strains, respectively. Further, the deletion of ompF or/and ompC in Delta mig-14 strains decreased their sensitivity to PB. Besides, the biofilm formation ability was reduced in Delta mig-14 strains. Our results indicate that Mig-14 may contribute to PB resistance in S. Typhi by decreasing the permeability of the outer membrane and promoting biofilm formation.
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