Related references
Note: Only part of the references are listed.CTCF boundary remodels chromatin domain and drives aberrant HOX gene transcription in acute myeloid leukemia
Huacheng Luo et al.
BLOOD (2018)
Self-interaction of NPM1 modulates multiple mechanisms of liquid-liquid phase separation
Diana M. Mitrea et al.
NATURE COMMUNICATIONS (2018)
Mutant NPM1 Maintains the Leukemic State through HOX Expression
Lorenzo Brunetti et al.
CANCER CELL (2018)
HOXA9 Reprograms the Enhancer Landscape to Promote Leukemogenesis
Yuqing Sun et al.
CANCER CELL (2018)
Leukemogenic nucleophosmin mutation disrupts the transcription factor hub that regulates granulomonocytic fates
Xiaorong Gu et al.
JOURNAL OF CLINICAL INVESTIGATION (2018)
Safety and efficacy of selinexor in relapsed or refractory multiple myeloma and Waldenstrom macroglobulinemia
Christine Chen et al.
BLOOD (2018)
KPT-8602, a second-generation inhibitor of XPO1-mediated nuclear export, is well tolerated and highly active against AML blasts and leukemia-initiating cells
J. Etchin et al.
LEUKEMIA (2017)
Efficient DNA binding of NF-κB requires the chaperone-like function of NPM1
Jianhuang Lin et al.
NUCLEIC ACIDS RESEARCH (2017)
DNMT3A in Leukemia
Lorenzo Brunetti et al.
COLD SPRING HARBOR PERSPECTIVES IN MEDICINE (2017)
SET1A/COMPASS and shadow enhancers in the regulation of homeotic gene expression
Kaixiang Cao et al.
GENES & DEVELOPMENT (2017)
Biological and clinical consequences of NPM1 mutations in AML
E. M. Heath et al.
LEUKEMIA (2017)
Molecular synergy underlies the co-occurrence patterns and phenotype of NPM1-mutant acute myeloid leukemia
Oliver M. Dovey et al.
BLOOD (2017)
A phase 1 clinical trial of single-agent selinexor in acute myeloid leukemia
Ramiro Garzon et al.
BLOOD (2017)
Nucleolin and nucleophosmin: nucleolar proteins with multiple functions in DNA repair
Daniel D. Scott et al.
BIOCHEMISTRY AND CELL BIOLOGY (2016)
Phase I Study of Selinexor, a Selective Inhibitor of Nuclear Export, in Combination With Fludarabine and Cytarabine, in Pediatric Relapsed or Refractory Acute Leukemia
Thomas B. Alexander et al.
JOURNAL OF CLINICAL ONCOLOGY (2016)
First-in-Class, First-in-Human Phase I Study of Selinexor, a Selective Inhibitor of Nuclear Export, in Patients With Advanced Solid Tumors
Albiruni R. Abdul Razak et al.
JOURNAL OF CLINICAL ONCOLOGY (2016)
Phase IB Study of Selinexor, a First-in-Class Inhibitor of Nuclear Export, in Patients With Advanced Refractory Bone or Soft Tissue Sarcoma
Mrinal M. Gounder et al.
JOURNAL OF CLINICAL ONCOLOGY (2016)
Next-generation XPO1 inhibitor shows improved efficacy and in vivo tolerability in hematological malignancies
Z. A. Hing et al.
LEUKEMIA (2016)
DNMT3A mutations promote anthracycline resistance in acute myeloid leukemia via impaired nucleosome remodeling
Olga A. Guryanova et al.
NATURE MEDICINE (2016)
Assessment of Minimal Residual Disease in Standard-Risk AML
A. Ivey et al.
NEW ENGLAND JOURNAL OF MEDICINE (2016)
Genomic Classification and Prognosis in Acute Myeloid Leukemia
Elli Papaemmanuil et al.
NEW ENGLAND JOURNAL OF MEDICINE (2016)
Targeting Chromatin Regulators Inhibits Leukemogenic Gene Expression in NPM1 Mutant Leukemia
Michael W. M. Kuhn et al.
CANCER DISCOVERY (2016)
Implication of NPM1 phosphorylation and preclinical evaluation of the nucleoprotein antagonist N6L in prostate cancer
Damien Destouches et al.
ONCOTARGET (2016)
14-3-3γ Prevents Centrosome Amplification and Neoplastic Progression
Amitabha Mukhopadhyay et al.
SCIENTIFIC REPORTS (2016)
Nucleophosmin integrates within the nucleolus via multi-modal interactions with proteins displaying R-rich linear motifs and rRNA
Diana M. Mitrea et al.
ELIFE (2016)
Epigenomic analysis of the HOX gene loci reveals mechanisms that may control canonical expression patterns in AML and normal hematopoietic cells
D. H. Spencer et al.
LEUKEMIA (2015)
Dactinomycin in NPM1-Mutated Acute Myeloid Leukemia
Brunangelo Falini et al.
NEW ENGLAND JOURNAL OF MEDICINE (2015)
Acute Myeloid Leukemia
Hartmut Doehner et al.
NEW ENGLAND JOURNAL OF MEDICINE (2015)
The RNA recognition motif of NIFK is required for rRNA maturation during cell cycle progression
Wen-An Pan et al.
RNA BIOLOGY (2015)
NPM1 histone chaperone is upregulated in glioblastoma to promote cell survival and maintain nucleolar shape
Karl Holmberg Olausson et al.
SCIENTIFIC REPORTS (2015)
Mouse models of NPM1-mutated acute myeloid leukemia: biological and clinical implications
P. Sportoletti et al.
LEUKEMIA (2015)
G-quadruplex DNA recognition by nucleophosmin: New insights from protein dissection
Pasqualina Liana Scognamiglio et al.
BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS (2014)
AF10 Regulates Progressive H3K79 Methylation and HOX Gene Expression in Diverse AML Subtypes
Aniruddha J. Deshpande et al.
CANCER CELL (2014)
Synergic Role of Nucleophosmin Three-helix Bundle and a Flanking Unstructured Tail in the Interaction with G-quadruplex DNA
Alessandro Arcovito et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Loss of Nucleolar Histone Chaperone NPM1 Triggers Rearrangement of Heterochromatin and Synergizes with a Deficiency in DNA Methyltransferase DNMT3A to Drive Ribosomal DNA Transcription
Karl Holmberg Olausson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2014)
Nucleo-cytoplasmic transport as a therapeutic target of cancer
Giovanni Luca Gravina et al.
JOURNAL OF HEMATOLOGY & ONCOLOGY (2014)
Nucleophosmin Contributes to the Transcriptional Activation Function of the Epstein-Barr Virus EBNA1 Protein
Natasha Malik-Soni et al.
JOURNAL OF VIROLOGY (2014)
Nucleophosmin modulates stability, activity, and nucleolar accumulation of base excision repair proteins
Mattia Poletto et al.
MOLECULAR BIOLOGY OF THE CELL (2014)
Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia
Liran I. Shlush et al.
NATURE (2014)
Identification of novel DNA-damage tolerance genes reveals regulation of translesion DNA synthesis by nucleophosmin
Omer Ziv et al.
NATURE COMMUNICATIONS (2014)
The human NPM1 mutation A perturbs megakaryopoiesis in a conditional mouse model
Paolo Sportoletti et al.
BLOOD (2013)
Clonal evolution in relapsed NPM1-mutated acute myeloid leukemia
Jan Kroenke et al.
BLOOD (2013)
The regulation of Hox gene expression during animal development
Moises Mallo et al.
DEVELOPMENT (2013)
Signatures of mutational processes in human cancer
Ludmil B. Alexandrov et al.
NATURE (2013)
Genomic and Epigenomic Landscapes of Adult De Novo Acute Myeloid Leukemia
Timothy J. Ley et al.
NEW ENGLAND JOURNAL OF MEDICINE (2013)
Identification and characterization of Hoxa9 binding sites in hematopoietic cells
Yongsheng Huang et al.
BLOOD (2012)
The Nuclear Chaperone Nucleophosmin Escorts an Epstein-Barr Virus Nuclear Antigen to Establish Transcriptional Cascades for Latent Infection in Human B Cells
Cheng-Der Liu et al.
PLOS PATHOGENS (2012)
The Multifunctional Protein Nucleophosmin (NPM1) Is a Human Linker Histone H1 Chaperone
Shrikanth S. Gadad et al.
BIOCHEMISTRY (2011)
Mutant nucleophosmin and cooperating pathways drive leukemia initiation and progression in mice
George S. Vassiliou et al.
NATURE GENETICS (2011)
The cytoplasmic NPM mutant induces myeloproliferation in a transgenic mouse model
Ke Cheng et al.
BLOOD (2010)
Nucleophosmin C-terminal Leukemia-associated Domain Interacts with G-rich Quadruplex Forming DNA
Luca Federici et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Nucleolar protein B23 has molecular chaperone activities
Attila Szebeni et al.
PROTEIN SCIENCE (2010)
Acetylated NPM1 Localizes in the Nucleoplasm and Regulates Transcriptional Activation of Genes Implicated in Oral Cancer Manifestation
Jayasha Shandilya et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
A dose-dependent tug of war involving the NPM1 leukaemic mutant, nucleophosmin, and ARF
N. Bolli et al.
LEUKEMIA (2009)
Altered nucleophosmin transport in acute myeloid leukaemia with mutated NPM1: molecular basis and clinical implications
B. Falini et al.
LEUKEMIA (2009)
Depletion of nucleophosmin leads to distortion of nucleolar and nuclear structures in HeLa cells
Mohammed Abdullahel Amin et al.
BIOCHEMICAL JOURNAL (2008)
Npm1 is a haploinsufficient suppressor of myeloid and lymphoid malignancies in the mouse
Paolo Sportoletti et al.
BLOOD (2008)
Arf-induced turnover of the nucleolar nucleophosmin-associated SUMO-2/3 protease Senp3
Mei-Ling Kuo et al.
CELL CYCLE (2008)
Structural Consequences of Nucleophosmin Mutations in Acute Myeloid Leukemia
Charles G. Grummitt et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Ribosomal protein S9 is a novel B23/NPM-binding protein required for normal cell proliferation
Mikael S. Lindstrom et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Nucleophosmin and its AML-associated mutant regulate c-Myc turnover through Fbw7γ
Paola Bonetti et al.
JOURNAL OF CELL BIOLOGY (2008)
Nucleophosmin Serves as a Rate-Limiting Nuclear Export Chaperone for the Mammalian Ribosome
Leonard B. Maggi et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
The structure and functions of NPM1/Nucleophsmin/B23, a multifunctional nucleolar acidic protein
Mitsuru Okuwaki
JOURNAL OF BIOCHEMISTRY (2008)
Crystal structure of human nucleophosmin-core reveals plasticity of the pentamer-pentamer interface
Hyung Ho Lee et al.
PROTEINS-STRUCTURE FUNCTION AND BIOINFORMATICS (2007)
Hox genes in hematopoiesis and leukemogenesis
B. Argiropoulos et al.
ONCOGENE (2007)
Translocations and mutations involving the nucleophosmin (NPM1) gene in lymphomas and leukemias
Brunangelo Falini et al.
HAEMATOLOGICA (2007)
Genome regulation by polycomb and trithorax proteins
Bernd Schuettengruber et al.
CELL (2007)
TSC1 sets the rate of ribosome export and protein synthesis through nucleophosmin translation
Corey L. Pelletier et al.
CANCER RESEARCH (2007)
Nucleophosmin acts as a novel AP2 alpha-binding transcriptional corepressor during cell differentiation
Hsuan Liu et al.
EMBO REPORTS (2007)
Acute myeloid leukemia:: Epidemiology and etiology
Barbara Deschler et al.
CANCER (2006)
Both carboxy-terminus NES motif and mutated tryptophan(s) are crucial for aberrant nuclear export of nucleophosmin leukemic mutants in NPMc+ AML
Brunangelo Falini et al.
BLOOD (2006)
Nucleophosmin is essential for ribosomal protein L5 nuclear export
Yue Yu et al.
MOLECULAR AND CELLULAR BIOLOGY (2006)
Delocalization and destabilization of the Arf tumor suppressor by the leukemia-associated NPM mutant
E Colombo et al.
CANCER RESEARCH (2006)
Mutations in nucleophosmin (NPM1) in acute myeloid leukemia (AML):: association with other gene abnormalities and previously established gene expression signatures and their favorable prognostic significance
RGW Verhaak et al.
BLOOD (2005)
Modulating Hox gene functions during animal body patterning
JC Pearson et al.
NATURE REVIEWS GENETICS (2005)
Nucleophosmin is required for DNA integrity and p19Arf protein stability
E Colombo et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Human histone chaperone nucleophosmin enhances acetylation-dependent chromatin transcription
V Swaminathan et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Temporal and spatial control of nucleophosmin by the Ran-Crm1 complex in centrosome duplication
W Wang et al.
NATURE CELL BIOLOGY (2005)
Acute myeloid leukemia bearing cytoplasmic nucleophosmin (NPMc+ AML) shows a distinct gene expression profile characterized by up-regulation of genes involved in stem-cell maintenance
M Alcalay et al.
BLOOD (2005)
Nucleophosmin/B23, a nuclear PI(3,4,5)P3 receptor, mediates the antiapoptotic actions of NGF by inhibiting CAD
JY Ahn et al.
MOLECULAR CELL (2005)
B23 regulates GADD45a nuclear translocation and contributes to GADD45a-induced cell cycle G2-M arrest
H Gao et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Role of nucleophosmin in embryonic development and tumorigenesis
S Grisendi et al.
NATURE (2005)
Cytoplasmic nucleophosmin in acute myelogenous leukemia with a normal karyotype.
B Falini et al.
NEW ENGLAND JOURNAL OF MEDICINE (2005)
N-terminal polyubiquitination and degradation of the Arf tumor suppressor
ML Kuo et al.
GENES & DEVELOPMENT (2004)
Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression
A Yokoyama et al.
MOLECULAR AND CELLULAR BIOLOGY (2004)
The structure and function of Xenopus NO38-core, a histone chaperone in the nucleolus
VMH Namboodiri et al.
STRUCTURE (2004)
Hypoxia-induced nucleophosmin protects cell death through inhibition of p53
J Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Disruption of the nucleolus mediates stabilization of p53 in response to DNA damage and other stresses
CP Rubbi et al.
EMBO JOURNAL (2003)
Tumor suppressor ARF degrades B23, a nucleolar protein involved in ribosome biogenesis and cell proliferation
K Itahana et al.
MOLECULAR CELL (2003)
Tryptophans 286 and 288 in the C-terminal region of protein B23.1 are important for its nucleolar localization
Y Nishimura et al.
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY (2002)
Nucleophosmin regulates the stability and transcriptional activity of p53
E Colombo et al.
NATURE CELL BIOLOGY (2002)
Proteins encoded by genes involved in chromosomal alterations in lymphoma and leukemia: clinical value of their detection by immunocytochemistry
B Falini et al.
BLOOD (2002)
Function of nucleophosmin/B23, a nucleolar acidic protein, as a histone chaperone
M Okuwaki et al.
FEBS LETTERS (2001)
The INK4a/ARF network in tumour suppression
CJ Sherr
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2001)
Nucleophosmin/B23 is a target of CDK2/Cyclin E in centrosome duplication
M Okuda et al.
CELL (2000)
Mapping the functional domains of nucleolar protein B23
K Hingorani et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Share Paper
