Journal
BIOCHEMISTRY
Volume 54, Issue 27, Pages 4163-4166Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.biochem.5b00560
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Funding
- National Institutes of Health [1R15CA159202-01]
- European Research Council [ERC 281556_Leukocyte Forces]
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CCL19 and CCL21 are chemokines involved in the trafficking of immune cells, particularly within the lymphatic system, through activation of CCR7. Concurrent expression of PSGL-1 and CCR7 in naive T-cells enhances recruitment of these cells to secondary lymphoid organs by CCL19 and CCL21. Here the solution structure of CCL19 is reported. It contains a canonical chemokine domain. Chemical shift mapping shows the N-termini of PSGL-1 and CCR7 have overlapping binding sites for CCL19 and binding is competitive. Implications for the mechanism of PSGL-1's enhancement of resting T-cell recruitment are discussed.
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