Journal
INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
Volume 121, Issue -, Pages 38-54Publisher
ELSEVIER
DOI: 10.1016/j.ijbiomac.2018.10.014
Keywords
Chitosan; Beta-glycerophosphate; Thermoresponsive hydrogel; Bone; Tissue engineering
Funding
- Department of Science and Technology, India, Inspire Faculty Program, Government of India [DST/INSPIRE/04/2017/002913]
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Tissue engineering (TE) is a promising approach for repairing diseased and damaged bone tissue. Injectable hydrogel based strategies offer a wide range of applications in rapid recovery of bone defects by acting as filler materials and depots for delivering various bioactive molecules and averting the need for surgical intervention. Chitosan (CS), a natural polysaccharide. forms a thermosensitive injectable hydrogel through the addition of beta-glycerophosphate (beta-GP). This hybrid hydrogel possesses numerous advantages namely mimicking native extracellular matrix (ECM) and providing an amenable microenvironment for cell growth. In this review, a brief insight into the gelation mechanism of CS/GP hydrogels, modifications, bioactive additives and their applications in treating bone defects are presented. (C) 2018 Elsevier B.V. All rights reserved.
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