Journal
BIOCHEMISTRY
Volume 54, Issue 10, Pages 1863-1878Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.biochem.5b00025
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Funding
- National Institutes of Health [GM50422]
- National Science Foundation
- Center for Molecular Electrocatalysis, an Energy Frontier Research Center - U.S. Department of Energy, Office of Science, Basic Energy Sciences
- Natural Sciences and Engineering Research Council of Canada [RGPIN05559]
- Simon Fraser University President's Research Startup Fund
- University of Washington
- Yale University
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R01GM050422, R56GM050422] Funding Source: NIH RePORTER
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An enormous variety of biological redox reactions are accompanied by changes in proton content at enzyme active sites, in their associated cofactors, in substrates and/or products, and between protein interfaces. Understanding this breadth of reactivity is an ongoing chemical challenge. A great many workers have developed and investigated biomimetic model complexes to build new ways of thinking about the mechanistic underpinnings of such complex biological proton-coupled electron transfer (PCET) reactions. Of particular importance are those model reactions that involve transfer of one proton (H+) and one electron (e(-)), which is equivalent to transfer of a hydrogen atom (H-center dot). In this Current Topic, we review key concepts in PCET reactivity and describe important advances in biomimetic PCET chemistry, with a special emphasis on research that has enhanced efforts to understand biological PCET reactions.
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