Journal
INFLAMMATORY BOWEL DISEASES
Volume 25, Issue 4, Pages 661-671Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/ibd/izy380
Keywords
IBD; autophagy; unfolded protein response; ER stress
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Funding
- Crohn's in Childhood Research Association PhD studentship
- National Health Service Research Scotland Career Researcher Fellowship - Chief Scientist Office
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Inflammatory bowel disease (IBD), which includes Crohn's disease (CD) and ulcerative colitis, is characterized by chronic inflammation of the gastrointestinal tract. The etiology involves a combination of genetic and environmental factors resulting in abnormal immune responses to intestinal microbiota. Genetic studies have strongly linked genes involved in autophagy to CD, and genes involved in the unfolded protein response (UPR) to IBD. The UPR is triggered in response to accumulation of misfolded proteins in the endoplasmic reticulum (ER), and autophagy plays a key role in relieving ER stress and restoring homeostasis. This review summarizes the known interactions between autophagy and the UPR and discusses the impact of these converging pathways on IBD pathogenesis. With a paucity of effective long-term treatments for IBD, targeting of synergistic pathways may provide novel and more effective therapeutic options.
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