Journal
INFLAMMATORY BOWEL DISEASES
Volume 25, Issue 5, Pages 820-830Publisher
OXFORD UNIV PRESS INC
DOI: 10.1093/ibd/izy327
Keywords
inflammatory bowel disease; Crohn's disease; ulcerative colitis; biological therapy; stem cells; safety
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Funding
- T32 Research Grant from the National Institutes of Health, National Institute of Diabetes and Digestive and Kidney Diseases [DK067872-11]
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Over the last 2 decades, novel therapies targeting several immune pathways have been developed for the treatment of patients with inflammatory bowel disease (IBD). Although anti-tumor necrosis factor (anti-TNF) agents remain the firstline treatment for moderate to severe Crohn's disease and ulcerative colitis, many patients will require alternative agents, due to nonresponse, loss of response, or intolerance of anti-TNFs. Furthermore, patients may request newer therapies due to improved safety profiles or improved administration (ie, less frequent injection, oral therapy). This review will focus on new and emerging therapies for the treatment of IBD, with a special focus on their adverse effects. Although many of the agents included in this paper have been approved for use in IBD, a few are still in development but have been shown to be effective in phase II clinical trials.
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