Journal
IMMUNOLOGICAL REVIEWS
Volume 287, Issue 1, Pages 236-240Publisher
WILEY
DOI: 10.1111/imr.12717
Keywords
CHAI; IBD; IL-10; IPEX; LATAIE; Treg
Categories
Funding
- Sidra Medicine
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Recently, several studies have investigated a number of rare monogenic autoimmune disorders, in which the causative genetic defects were identified and found to affect the development or function of regulatory T cells (Tregs). The studies of these disorders have facilitated a deeper understanding of the mechanisms involved in immune regulation and tolerance. Furthermore, these studies have highlighted the importance of Tregs in maintaining homeostasis at the mucosal interface between the host and microbiome. Here, we offer our perspective on these monogenic autoimmune disorders, highlighting their overlapping clinical features with inflammatory bowel disease.
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