Journal
BIOCHEMISTRY
Volume 54, Issue 41, Pages 6295-6298Publisher
AMER CHEMICAL SOC
DOI: 10.1021/acs.biochem.5b00851
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Funding
- Russian Science Foundation [14-14-00573]
- Russian Science Foundation [14-14-00573] Funding Source: Russian Science Foundation
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The epidermal growth factor receptor (EGFR) is one of the most extensively studied receptor tyrosine kinases, as it is involved in a wide range of cellular processes and severe diseases. Recent works reveal that the single-helix transmembrane domains and cytoplasmic juxtamembrane regions play an important role in the receptor activation process. Here we present the results of our investigation of the spatial structure and mobility of the EGFR transmembrane domain and juxtamembrane regions in various membranelike environments, which shed light on the effects of the membrane physical properties and composition on the behavior of the juxtamembrane domain.
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