Journal
HUMAN PATHOLOGY
Volume 86, Issue -, Pages 163-169Publisher
W B SAUNDERS CO-ELSEVIER INC
DOI: 10.1016/j.humpath.2019.01.001
Keywords
GATA6; Ovarian cancer; Prognosis; Stem cell and lineage differentiation factor
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Funding
- National Cancer Institute Cancer Center Support Grant [CA016672]
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Ovarian cancer (OC) is the main cause of gynecological cancer-associated mortality. Improving the diagnosis is important for guiding clinical treatment. The present study aimed to investigate the relationship between expression of GATA6, a stem cell factor, and its prognosis in OC. In total, 521 OC cases were included. Immunohistochemistry analysis demonstrated that GATA6 was expressed in both high-grade serous carcinoma as well as non-serous tumors. High grade serous carcinoma showed a higher percentage of GATA6 positive staining. Positive staining of GATA6 showed worse overall survival (OS) in all ovarian cancers or serous and non-serous carcinoma individually. GATA6 was revealed as an independent risk factor for prognosis by multivariate Cox analysis. In all, GATA6 may present as a novel marker for poor prognosis in OC. (C) 2019 Elsevier Inc. All rights reserved.
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