Journal
HAEMATOLOGICA
Volume 104, Issue 2, Pages 226-235Publisher
FERRATA STORTI FOUNDATION
DOI: 10.3324/haematol.2018.197152
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Funding
- Instituto de Salud Carlos III (ISCIII) of the Spanish Ministry of Economy and Competence (MINECO)
- RTICC ISCIII
- (CIBERONC) [SAF2013-47416-R, RD06/0020/0107-RD012/0036/0060, I+D+I: PI17/2172, PI16/01294, PIE15/0081]
- Madrid Autonomous Community
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Primary cutaneous CD30-positive T-cell lymphoproliferative disorders are the second most common subgroup of cutaneous T-cell lymphomas. They include two clinically different entities with some overlapping features and borderline cases: lymphomatoid papulosis and primary cutaneous anaplastic large cell lymphoma. Molecular studies of primary cutaneous anaplastic large cell lymphoma reveal an increasing level of heterogeneity that is associated with histological and immunophenotypic features of the cases and their response to specific therapies. Here, we review the most significant genetic, epigenetic and molecular alterations described to date in primary cutaneous CD30-positive T-cell lymphoproliferative disorders, and their potential as therapeutic targets.
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