Journal
GLIA
Volume 67, Issue 4, Pages 571-581Publisher
WILEY
DOI: 10.1002/glia.23509
Keywords
demyelination; myelin exocytosis; peripheral neuropathy; Schwann cells; segmental demyelination; Wallerian degeneration
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Funding
- National Research Foundation of Korea (NRF) [2016R1A5A2007009]
- ATIP-Avenir Program
- European Research Council [FP7-IDEAS-ERC 311610]
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Myelinating Schwann cells undergo irreversible demyelination in many demyelinating neuropathies that show complete demyelination of the internode. Dedifferentiation, reprogramming, and myelin clearance processes-which are specifically discussed in this article-appear to be shared by various demyelinating peripheral conditions, such as Wallerian degeneration, immune-mediated, and toxic demyelinating diseases. We propose to introduce the concept of the demyelinating Schwann cell (DSC) as a novel cell phenotype, which has specific properties required for myelin sheath clearance. We anticipate that the introduction of the DSC concept will provide a significant advance in understanding the pathophysiological mechanisms of demyelinating peripheral neuropathies.
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