Journal
GENES CHROMOSOMES & CANCER
Volume 58, Issue 1, Pages 66-69Publisher
WILEY
DOI: 10.1002/gcc.22687
Keywords
diffuse large B-cell lymphoma; epigenetics; methylation; primary central nervous system lymphoma
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Funding
- German Ministry for Education and Science (BMBF) [01KU1505G, 01KU1002A-J]
- Deutsche Krebshilfe [70112053]
- Kinderkrebsinitiative Buchholz/Holm-Seppensen
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Primary lymphomas of the central nervous system (PCNSL) are diffuse large B-cell lymphomas (DLBCLs) confined to the central nervous system (CNS). We here performed array-based DNA methylation analyses of 26 PCNSL and 78 DLBCL and validated our findings in an independent dataset. We identified 2847 CpGs differentially methylated between PCNSL and non-CNS-DLBCL. Neither a supervised analysis using these CpGs nor application of 3 CpG classifiers selected for class separation unambiguously separated PCNSL from non-CNS-DLBCL. Remarkably, 6/78 non-CNS-DLBCL consistently segregated with PCNSL, which displayed molecular features typical for PCNSL. Our findings suggest that a subset of non-CNS-DLBCL exists which molecularly resembles PCNSL.
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