Journal
GENES & DEVELOPMENT
Volume 33, Issue 1-2, Pages 1-3Publisher
COLD SPRING HARBOR LAB PRESS, PUBLICATIONS DEPT
DOI: 10.1101/gad.322990.118
Keywords
KRAB zinc finger proteins; ZFP445; ZFP57; genomic imprint maintenance; resistance to epigenetic reprogramming
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Funding
- NICHD NIH HHS [T32 HD083185] Funding Source: Medline
- NIEHS NIH HHS [P30 ES013508] Funding Source: Medline
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The monoallelic parent of origin-specific expression of imprinted genes in mammals is regulated by differentially DNA methylated imprinting control regions (ICRs). In contrast to most of the genome, ICRs must maintain their DNA methylation and parental identity despite extensive epigenetic reprogramming that takes place after fertilization. Previous work demonstrated that the Kruppel-associated box (KRAB)-containing zinc finger protein (KZFP) ZFP57 protects select ICRs from demethylation and preserves parental identity. However, some loci are unaffected in Zfp57-null mice. Thus, it has been speculated that other KZFPs must be involved in this process. Takahashi and colleagues (pp. 49-54) now report one such KZFP: ZFP445.
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