Journal
FUTURE MICROBIOLOGY
Volume 13, Issue 15, Pages 1637-1646Publisher
FUTURE MEDICINE LTD
DOI: 10.2217/fmb-2018-0200
Keywords
antifungal; cytotoxicity; embryotoxicity; geraniol; linalool
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Funding
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [2007/54241-8]
- Conselho Nacional de Desenvolvimento Cientifico e Tecnologico (CNPq)
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Aim: Geraniol and linalool are major constituents of the essential oils of medicinal plants. Materials & methods: Antifungal activity of geraniol and linalool were evaluated against five Candida species. The genotoxicity of these compounds was evaluated by the cytokinesis-block micronucleus test, and the embryotoxic assays use zebrafish model. Results: Geraniol and linalool inhibited Candida growth, but geraniol was more effective. The geraniol at concentration of 800g/ml and the linalool at concentration of 125g/ml significantly increased chromosome damage. Geraniol was more toxic to zebrafish embryo than linalool: LC50 values were 31.3 and 193.3g/ml, respectively. Conclusion: Geraniol and linalool have anticandidal activity, but they also exert genotoxic and embryotoxic effects at the highest tested concentrations. [GRAPHICS] .
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