Journal
COMPUTATIONAL PARTICLE MECHANICS
Volume 2, Issue 4, Pages 401-444Publisher
SPRINGER INTERNATIONAL PUBLISHING AG
DOI: 10.1007/s40571-015-0082-3
Keywords
Cell mechanics; Agent-based modeling; Lattice-based models; Lattice-free models; Deformable cell models; Hybrid models
Funding
- EU NOTOX
- ANR INVADE
- ANR PHYSCANCER
- BMBF Virtual Liver
- BMBF Cancersys/Lungsys
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In this paper we present an overview of agent-based models that are used to simulate mechanical and physiological phenomena in cells and tissues, and we discuss underlying concepts, limitations, and future perspectives of these models. As the interest in cell and tissue mechanics increase, agent-based models are becoming more common the modeling community. We overview the physical aspects, complexity, shortcomings, and capabilities of the major agent-based model categories: lattice-based models (cellular automata, lattice gas cellular automata, cellular Potts models), off-lattice models (center-based models, deformable cell models, vertex models), and hybrid discrete-continuum models. In this way, we hope to assist future researchers in choosing a model for the phenomenon they want to model and understand. The article also contains some novel results.
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