Journal
FITOTERAPIA
Volume 131, Issue -, Pages 204-208Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.fitote.2018.10.027
Keywords
Aspergillus sp.; Globoscinic acid derivatives; Cytotoxic activity; ECD calculation
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Funding
- Open Fund of State Key Laboratory of Phytochemistry and Plant Resources in West China [P2017-KF03]
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Five novel globoscinic acid derivatives, aspergilates A-E (1-5) have been isolated from endophytic fungus Aspergillus sp. derived from Paeonia ostii. The structures of aspergilates A-E were determined by in-depth analyses of NMR spectra, HRESIMS and CD experiments. The absolute configurations of compounds 2-5 were determined by the ECD calculations based on quantum chemistry. Cytotoxic activities against five selected tested tumor cell lines of 1-5 were evaluated.
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