Journal
FEBS LETTERS
Volume 593, Issue 1, Pages 23-41Publisher
WILEY
DOI: 10.1002/1873-3468.13294
Keywords
cancer metabolism; constraint-based reconstruction and modeling; retinoblastoma; synthetic lethal; systems biology
Funding
- DST-INSPIRE Faculty award, Department of Science and Technology, India [DST/INSPIRE/04/2015/000036, BT/01/CEIB/11/V/16]
- Department of Biotechnology, India [BT/01/CEIB/11/V/16]
- DST-SERB [EMR/2015/00607]
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Retinoblastoma (RB) is a childhood eye cancer. Currently, chemotherapy, local therapy, and enucleation are the main ways in which these tumors are managed. The present work is the first study that uses constraint-based reconstruction and analysis approaches to identify and explain RB-specific survival strategies, which are RB tumor specific. Importantly, our model-specific secretion profile is also found in RB1-depleted human retinal cells in vitro and suggests that novel biomarkers involved in lipid metabolism may be important. Finally, RB-specific synthetic lethals have been predicted as lipid and nucleoside transport proteins that can aid in novel drug target development.
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