Journal
FEBS LETTERS
Volume 593, Issue 4, Pages 406-413Publisher
WILEY
DOI: 10.1002/1873-3468.13323
Keywords
colon cancer; deubiquitination; MSI2; proliferation; USP10
Funding
- National Natural Science Foundation of China [81220108021, 2017ZX10203206]
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Recent studies have demonstrated that ubiquitin-specific protease 10 (USP10) plays a catalytic role in tumour suppression mainly by deubiquitinating its target proteins to enhance their stabilities. However, we found that USP10 could interact with and regulate the expression of oncogenic factor Musashi-2 (MSI2). We investigated whether USP10 positively regulates the expression of MSI2 by deubiquitination and confirmed the type of polyubiquitin chain that is linked to MSI2. We also explored the role of USP10 in regulating the proliferation of colon cancer through different experiments. This study provides a completely new perspective in understanding the role of USP10 in deubiquitination. In the future, USP10 may serve as a target for colon cancer treatment.
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