Journal
FEBS LETTERS
Volume 592, Issue 24, Pages 4078-4086Publisher
WILEY
DOI: 10.1002/1873-3468.13278
Keywords
Drosophila melanogaster; environmental response; gut microbiota; host-microbiome interaction
Funding
- Knut and Alice Wallenberg Foundation
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Environmental perturbations induce transcriptional changes, some of which may be inherited even in the absence of the initial stimulus. Previous studies have focused on transfers through the germline although microbiota is also passed on to the offspring. Thus, we inspected the involvement of the gut microbiome in transgenerational inheritance of environmental exposures in Drosophila melanogaster. We grew flies in the cold versus control temperatures and compared their transcriptional patterns in both conditions as well as in their offspring. F2 flies grew in control temperature, while we controlled their microbiota acquisition from either F1 sets. Transcriptional status of some genes was conserved transgenerationally, and a subset of these genes, mainly expressed in the gut, was transcriptionally dependent on the acquired microbiome.
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