Journal
EXPERT OPINION ON INVESTIGATIONAL DRUGS
Volume 28, Issue 2, Pages 191-205Publisher
TAYLOR & FRANCIS LTD
DOI: 10.1080/13543784.2019.1557147
Keywords
Cyclooxygenase (COX); epilepsy; spontaneous recurrent seizures; antiepileptic; antiepileptogenic; proconvulsant
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Introduction: Neuroinflammation has a critical role in brain disorders. Cyclooxygenase (COX) is one of the principal drug targets for the reduction of neuroinflammation; however, studies have yielded mixed results for COX-inhibitors in the treatment of diverse acute and chronic models of epilepsy.Areas covered: The article covers the effects of COX-inhibitors in epilepsy disorders. A considerable emphasis has been placed on the antiepileptic and disease-modifying' properties of COX-1 and COX-2 inhibitors in various preclinical epilepsy models.Expert opinion: The effect of COX-inhibitors on epilepsy is inconclusive. Studies have indicated beneficial effects in preclinical models; however, proconvulsant or no effects have also been observed. These molecules may have a bidirectional role with early neuroprotective and delayed neurotoxic effects. Further systematic preclinical studies to establish the use of COX-inhibitors in epilepsy are necessary.
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