Journal
EXERCISE AND SPORT SCIENCES REVIEWS
Volume 47, Issue 2, Pages 108-115Publisher
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1249/JES.0000000000000181
Keywords
fiber branching; hyperplasia; satellite cells; regeneration; Pax7-DTA
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Funding
- NIH [AR071753, AR60701]
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Skeletal muscle fiber branching and splitting typically is associated with damage and regeneration and is considered pathological when observed during loading-induced hypertrophy. We hypothesize that fiber splitting is a nonpathological component of extreme loading and hypertrophy, which is primarily supported by evidence in animals, and propose that the mechanisms and consequences of fiber splitting deserve further exploration.
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