Journal
EUROPEAN RESPIRATORY JOURNAL
Volume 53, Issue 1, Pages -Publisher
EUROPEAN RESPIRATORY SOC JOURNALS LTD
DOI: 10.1183/13993003.01887-2018
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Funding
- NATIONAL HEART, LUNG, AND BLOOD INSTITUTE [P01HL014985, R01HL074186, R01HL122887, P01HL108797, R01HL138473] Funding Source: NIH RePORTER
- NHLBI NIH HHS [R01 HL122887, P01 HL014985, R01 HL074186, R01 HL138473, P01 HL108797] Funding Source: Medline
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Clinical and translational research has played a major role in advancing our understanding of pulmonary hypertension (PH), including pulmonary arterial hypertension and other forms of PH with severe vascular remodelling (e. g. chronic thromboembolic PH and pulmonary veno- occlusive disease). However, PH remains an incurable condition with a high mortality rate, underscoring the need for a better transfer of novel scientific knowledge into healthcare interventions. Herein, we review recent findings in pathology (with the questioning of the strict morphological categorisation of various forms of PH into pre- or post- capillary involvement of pulmonary vessels) and cellular mechanisms contributing to the onset and progression of pulmonary vascular remodelling associated with various forms of PH. We also discuss ways to improve management and to support and optimise drug development in this research field.
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