Journal
EUROPEAN JOURNAL OF PHARMACOLOGY
Volume 843, Issue -, Pages 277-284Publisher
ELSEVIER SCIENCE BV
DOI: 10.1016/j.ejphar.2018.11.024
Keywords
Insulin resistance; Ginsenoside-Rg1; Glucose metabolism; Signaling pathway
Categories
Funding
- National Natural Science Foundation of China [81360128]
- Basic Research in Yunnan Province [2013FZ052]
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Insulin resistance is a major pathophysiological feature in the development of type 2 diabetes. The liver is an important organ responsible for the development of insulin resistance, and exploring liver glucose metabolism is important to study insulin resistance. We first established the model of insulin resistance in HepG2 cells and then treated them with different concentrations of ginsenoside-Rg1. The results showed that ginsenoside-Rg1 is not toxic to HepG2 cells. In addition, ginsenoside-Rg1 relieved the insulin-induced insulin resistance in HepG2 cells. Furthermore, ginsenoside-Rg1 increased the uptake of glucose by reducing reactive oxygen species and down-regulating the phosphorylation level of p38 MAPK. In addition, ginsenoside-Rg1 also decreased the output of glucose by increasing Akt phosphorylation and reducing GSK3 beta expression. In conclusion, ginsenoside-Rg1 can alleviate the insulin resistance through increasing the uptake of glucose and decreasing the output of glucose.
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