Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2019, Issue 1, Pages 32-35Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201801412
Keywords
Aldehydes; Nitrile; Iron carbonyl; CO surrogate; Reductive alkylation; Reduction; Carbonyl ligands
Categories
Funding
- RFBR [18-33-00037]
- Korea Science Academy of KAIST
- Ministry of Science and ICT
- RUDN 5-100 program
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A new protocol for the synthesis of nitriles from carbonyl compounds with elongation of the molecule with two carbon atoms was developed. It involves a reaction of ethyl cyanoacetate with different aldehydes in the presence of iron pentacarbonyl as a reducing agent. This protocol is very simple and requires only commonly available reagents, with no catalyst or complicated ligands being employed.
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