Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2018, Issue 43, Pages 5980-5987Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201801095
Keywords
Nanoparticles; Michael addition; Functionalized magnetite; Hexamethylenetetramine; Heterogeneous catalysis
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Funding
- Board of Research in Nuclear Science (BRNS), DAE, India
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Polymer-encapsulated magnetite nanoparticles bearing Hexamethylenetetramine (Fe3O4@HMTA) have been developed for catalysing the aza-Michael addition to form beta-amino compounds. The effects of solvent, amount and reuse on catalytic activity of the Fe3O4@HMTA have been studied. The catalytic activity of the Fe3O4@HMTA has not deteriorated during successive recycling. Eight different substrates have been subjected to aza-Michael additions, and yields of the products in the range of 50-90 % have been observed in the presence of catalyst depending upon the substituent groups in the reactants. The formation of a single chiral adduct by reacting a acrylamide derivative of l-proline benzyl ester with morpholine seems to suggest that the reaction conditions preclude the racemization of products.
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