Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2019, Issue 6, Pages 1350-1354Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201801689
Keywords
Continuous flow; Microreactors; Synthetic methods; Phenothiazine; Heterocycles
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Funding
- Agency for Innovation by Science and Technology in Flanders (IWT)
- 3M
- Fund for Scientific Research-Flandres (FWO)
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The continuous flow synthesis of a model phenothiazine antipsychotic is presented herein, using 3-chloropropionyl chloride as a central building block. The basic phenothiazine-derived scaffold is (atom)-efficiently and mildly synthesized with the aim to present continuous flow technology as a contributor to fast and efficient syntheses of challenging APIs, that are nowadays experiencing supply disruptions and global shortages.
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