Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2019, Issue 4, Pages 705-714Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201801292
Keywords
Nitrogen heterocycles; Domino reactions; Coumarin; Quinolinones; Cyclization
Categories
Funding
- Science and Engineering Research Board (SERB), New Delhi [EMR/2017/000598]
- UGC, New Delhi
Ask authors/readers for more resources
A concise cascade strategy for the synthesis of 6H-chromeno[4,3-b]quinolin-6-ones was developed from 4-hydroxycoumarins and arylhydrazine hydrochlorides in DMSO. The synthetic strategy relies on dual role of ammonium acetate in generating 4-aminophenyl coumarin from arylhydrazine via aryl radical formation, and Csp(2)-H formylation of coumarin using DMSO as a methine source. The strategy is scalable, and an array of arylhydrazine hydrochlorides delivered chromene-fused quinolinones in good to excellent yields.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available