Journal
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY
Volume 2019, Issue 6, Pages 1330-1334Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/ejoc.201801662
Keywords
Amides; Rearrangement; Fluorine
Categories
Funding
- National Natural Science Foundation of China [21772022]
- Fuzhou University
Ask authors/readers for more resources
A method for the synthesis of N-trifluoroacetyl amides through trifluoroacetic anhydride transfer to nitrones by borrowing and returning oxygen atom is reported. The reaction appears to proceed via electrophilic trifluoroacetylation, followed by nucleophilic addition and elimination, and intramolecular substitution, affording N-trifluoroacetyl amides in good to excellent yields. The present method tolerates a wide range of functional groups. Also, nitrones react with difluoroacetic anhydride providing the corresponding N-difluoroacetyl amides. Moreover, the method described could be of interest from a biological point of view, because it constitutes a straightforward strategy for the synthesis of biologically active N-trifluoroacetyl amide analogues.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available