Journal
EUROPEAN JOURNAL OF CLINICAL PHARMACOLOGY
Volume 75, Issue 2, Pages 171-178Publisher
SPRINGER HEIDELBERG
DOI: 10.1007/s00228-018-2570-x
Keywords
Atorvastatin; Skin toxicity; Radiotherapy; Radioprotective
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Funding
- Mazandaran University of Medical Science, Sari, Iran
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Background and purposeThe purpose of this randomized, placebo-controlled, double-blind study was to investigate the preventive effect of topical administration of atorvastatin (ATV) on the acute radiation-induced skin toxicity in patients with breast cancer.Patients and methodsSeventy breast cancer patients were randomly assigned to use topical ATV 1% or placebo gels during radiotherapy twice daily. Radiation-induced dermatitis was classified according to the radiation therapy oncology group (RTOG) criteria, as well as pain and itching were scored according to VAS (visual analogue scale) for 6weeks of treatment.ResultsTopical administration of ATV gel during radiotherapy reduced significantly radiation-induced breast swelling, itching, and pain in breast cancer patients by factors of 1.8, 1.7, and 1.5, respectively. ATV reduced the redness caused by radiotherapy in patients as compared with placebo; however, this difference was statistically not significant.ConclusionATV was able to reduce significantly itching, breast edema, and pain in patients during radiotherapy.
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