Journal
WORLD JOURNAL OF GASTROINTESTINAL ONCOLOGY
Volume 7, Issue 11, Pages 347-355Publisher
BAISHIDENG PUBLISHING GROUP INC
DOI: 10.4251/wjgo.v7.i11.347
Keywords
Inherited polyposis syndromes; Hereditary cancer; Stomach; Intestine; Colorectal
Categories
Funding
- University of Medicine and Pharmacy of Tirgu-Mures, Romania [UMFTGM-PO-CC-02-F01, 19/2014]
Ask authors/readers for more resources
Because of the rarity of familial gastrointestinal cancerpredisposing syndromes, their exploration in literature is not extensive. In this review, an update of the clinicopathological and molecular criteria of gastrointestinal familial polyposis syndromes with potential malignant transformation is performed. In addition, a guide for screening and surveillance was synthesized and a distribution of gene mutations according to the specific syndromes and geographic distribution was included. The following inherited polyposes syndromes were analyzed: familial adenomatous polyposis, the hamartomatous familial polyposes (Juvenile polyposis, Peutz-Jeghers syndrome, Cowden syndrome, BannayanRiley- Ruvalcaba syndrome, hereditary mixed polyposis syndrome, Gorlin syndrome, Birt-Hogg-Dube syndrome, neurofibromatosis type. and multiple endocrine neoplasia syndrome 2B), Li-Fraumeni syndrome, and MUTYHassociated adenomatous polyposis. For proper medical care, subspecialization of gastroenterologists, pathologists, and genticists in the field of familial diseases should be introduced in the medical curriculum.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available