Journal
ELECTROANALYSIS
Volume 31, Issue 4, Pages 646-651Publisher
WILEY-V C H VERLAG GMBH
DOI: 10.1002/elan.201800784
Keywords
Dipyrone; graphene; pharmaceutical formulations; amperometry
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Funding
- FAPEMIG (Research Support Foundation of the State of Minas Gerais) [APQ-02010-16]
- CNPq (National Council for Scientific and Technological Development)
- CAPES (Coordination for the Improvement of Higher Education Personnel)
- PROPESQ/UFJF
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Dipyrone (metamizole sodium) is one of the most consumed drugs in the world. In this work a novel analytical method was developed for dipyrone sensing. This method involves the amperometric detection on a chemically-reduced graphene-oxide (CRGO)-modified glassy carbon electrode. Raman spectroscopy and scanning electron microscopy revealed the presence of multilayer graphene layers that contributed to the electrocatalytic oxidation of dipyrone and increase in the electroactive area. Advantages of this sensor include elimination of previous separations, solvent extraction, or sample filtration, low detection limit (0.13 mu mol L-1) with a linear range from 48 to 246 mu mol L-1 and adequate recovery values (97-103 %). Applied to commercial pharmaceutical samples, this method showed results ranging from 451 to 541 mg of dipyrone per tablet, which agreed with the expected values. The results obtained by amperometry were compared statistically with the official method recommended by the Brazilian Pharmacopoeia (iodometric method), with no significant differences between them at 95 % confidence level. The proposed method is accurate for the monitoring of sodium dipyrone in pharmaceutical formulations, highlighting the lower reagent consumption and interferences in the analytical process.
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