Journal
BIOCHEMICAL SOCIETY TRANSACTIONS
Volume 43, Issue -, Pages 64-72Publisher
PORTLAND PRESS LTD
DOI: 10.1042/BST20140324
Keywords
myosin; hypertrophic cardiomyopathy
Categories
Funding
- National Institutes of Health [GM33289, HL117138]
Ask authors/readers for more resources
No matter how many times one explores the structure of the myosin molecule, there is always something new to discover. Here, I describe the myosin mesa, a structural feature of the motor domain that has the characteristics of a binding domain for another protein, possibly myosin-binding protein C (MyBP-C). Interestingly, many well-known hypertrophic cardiomyopathy (HCM) mutations lie along this surface and may affect the putative interactions proposed here. A potential unifying hypothesis for the molecular basis of human hypertrophic cardiomyopathy is discussed here. It involves increased power output of the cardiac muscle as a result of HCM mutations causing the release of inhibition by myosin binding protein C.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available