Journal
DYES AND PIGMENTS
Volume 160, Issue -, Pages 28-36Publisher
ELSEVIER SCI LTD
DOI: 10.1016/j.dyepig.2018.07.048
Keywords
Water-soluble perylene diimide (PDI) fluorophore; Selective pH probe; Photoinduced electron transfer (PET); Cytotoxicity; Cells permeability
Funding
- Science Foundation at the University of Chemical Technology and Metallurgy (Sofia, Bulgaria) [11721/2017, 11724/2017]
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Herein we pay attention to the design, synthesis and sensor activity of a novel biocompatible perylene-3,4,9,10-tetracarboxylic diimide (PDI) pH-probe in water. The synthesized compound shows selective fluorescence signalling properties as a function of pH (pK(a) value of 6.35 +/- 0.02) which makes the probe suitable for pH determination in the physiological range. Thus prepared water soluble fluorescent system demonstrate low cytotoxicity to L929 cell lines from 330 mu M to 1.3 mu M and cell permeability in the lower concentration range. That findings show the high potential of the newly prepared PDI probe for monitoring of pH variations in bio-samples.
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