Journal
DRUG DEVELOPMENT RESEARCH
Volume 80, Issue 1, Pages 6-10Publisher
WILEY
DOI: 10.1002/ddr.21465
Keywords
antibacterial; antimicrobial resistance; drug design; Mur ligases; MurA; MurB
Categories
Funding
- Slovenian Research Agency [Z1-8158, P1-0208]
Ask authors/readers for more resources
The increase of antimicrobial resistance necessitates the renewal and strong research involvement in antibacterial drug design. In the following work, we comment on the key approaches used in development of new antibacterials, focusing on intracellular therapeutic targets that have been so far mostly underexplored: the enzymes of the Mur pathway MurA to MurF. We identify common obstacles observed during research on MurA, MurB, and Mur ligases inhibitors and their development into potential antibacterial compounds, and discern several approaches and solutions to tackle the whole-cell activity of designed compounds. Furthermore, we consolidate recent literature reports and encourage the further research on Mur enzymes.
Authors
I am an author on this paper
Click your name to claim this paper and add it to your profile.
Reviews
Recommended
No Data Available