Journal
DIGESTIVE DISEASES AND SCIENCES
Volume 64, Issue 6, Pages 1640-1650Publisher
SPRINGER
DOI: 10.1007/s10620-018-5432-6
Keywords
Crohn's disease; Postsurgical recurrence; Bowel sonography; Contrast-enhanced ultrasound
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PurposeThe aim was to investigate the contribution of contrast-enhanced ultrasound (CEUS) to improve the results of US in the evaluation of recurrence in postsurgical Crohn's disease (CD) and establish its role in the assessment of the severity.MethodsAnastomotic site was assessed in 108 postsurgical CD patients with B-mode, color Doppler and CEUS. Bowel wall thickness (WT), transmural complications or stenosis, color Doppler grade, and bowel wall contrast enhancement (BWCE)using time-intensity curveswere correlated with endoscopic Rutgeerts score. A receiver operating characteristic (ROC) curve was built to establish the best cutoff to predict recurrence and the severity. A US scoring system was elaborated in order to determine the grade of recurrence.ResultsIleocolonoscopy detected recurrence in 90 (83.3%) subjects and severe recurrence in 62. WT3mm had an accuracy of 90.7% in the detection of endoscopic recurrence. The combination of parametersWT3mm and BWCE (46%)demonstrated similar accuracy (90.7%). A WT5mm showed the best specificity (100%) for the diagnosis of recurrence and a WT6mm the best specificity (95.7%) for the detection of severe recurrence. The combination of sonographic parametersWT6mm or WT between 5 and 6mm with BWCE70%, or complicationsobtained the best results grading the recurrence (sensitivity, specificity, and accuracy of 90.3%, 87%, and 88.9%, respectively).ConclusionsUS shows high sensitivity and specificity for the diagnosis of postsurgical recurrence. When combined with CEUS, it can improve the detection of severe recurrence.
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