Journal
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
Volume 94, Issue 1, Pages 81-85Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.diagmicrobio.2018.11.011
Keywords
Synergism; Carbapenemases; Polymyxin B; Tigecycline; Meropenem
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Funding
- Fundo de Incentivo a Pesquisa e Eventos do Hospital de Clinicas de Porto Alegre (FIPE/HCPA)
- Coordencao de Aperfeicoamento de Pessoal de Ensino Superior (CAPES), Brazil
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Here, we evaluated the combinations of antibiotics polymyxin B (PMB), tigecycline (TGC) and meropenem (MEM) by time-kill curves (MC) against carbapenem-resistant Enterobacter cloacae isolates. Combination of PMB/TGC and PMB/MEM showed promising results in sub-inhibitory concentration of PMB indicating the possibility of reducing the dose of PMB used in the treatment. (C) 2018 Elsevier Inc. All rights reserved.
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