Minimal inhibitory concentration of omadacycline and doxycycline against bacterial isolates with known tetracycline resistance determinants

Omadacycline is an aminomethylcycline derived from the tetracycline class. The minimum inhibitory concentration of 115 Enterobacteriaceae and Staphylococcus aurcus isolates with known tetracycline resistance determinants against omadacycline and doxycycline was determined by broth microdilution. Omadacycline is, on a weight basis, more active than doxycycline for nearly all isolates, and differences in activity correlated with organism rather than resistance mechanism. (C) 2018 Elsevier Inc. All rights reserved.