Journal
DIAGNOSTIC MICROBIOLOGY AND INFECTIOUS DISEASE
Volume 94, Issue 1, Pages 78-80Publisher
ELSEVIER SCIENCE INC
DOI: 10.1016/j.diagmicrobio.2018.11.010
Keywords
MIC; Omadacycline; Doxycycline; Resistance
Categories
Funding
- Paratek Pharmaceuticals, Inc, USA
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Omadacycline is an aminomethylcycline derived from the tetracycline class. The minimum inhibitory concentration of 115 Enterobacteriaceae and Staphylococcus aurcus isolates with known tetracycline resistance determinants against omadacycline and doxycycline was determined by broth microdilution. Omadacycline is, on a weight basis, more active than doxycycline for nearly all isolates, and differences in activity correlated with organism rather than resistance mechanism. (C) 2018 Elsevier Inc. All rights reserved.
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