Journal
DEVELOPMENTAL CELL
Volume 47, Issue 4, Pages 453-+Publisher
CELL PRESS
DOI: 10.1016/j.devcel.2018.10.025
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Funding
- Spanish Ministry of Economy, Industry and Competitiveness (MEIC)
- Centro de Excelencia Severo Ochoa [BFU2010-16546, BFU2015-68754]
- CERCA Programme/Generalitat de Catalunya
- Francis Crick Institute
- Cancer Research UK [FC001317]
- UK Medical Research Concil [FC001317]
- Wellcome Trust [FC001317]
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During epithelial contraction, cells generate forces to constrict their surface and, concurrently, fine-tune the length of their adherens junctions to ensure force transmission. While many studies have focused on understanding force generation, little is known on how junctional length is controlled. Here, we show that, during amnioserosa contraction in Drosophila dorsal closure, adherens junctions reduce their length in coordination with the shrinkage of apical cell area, maintaining a nearly constant junctional straightness. We reveal that junctional straightness and integrity depend on the endocytic machinery and on the mechanosensitive activity of the actomyosin cytoskeleton. On one hand, upon junctional stretch and decrease in E-cadherin density, actomyosin relocalizes from the medial area to the junctions, thus maintaining junctional integrity. On the other hand, when junctions have excess material and ruffles, junction removal is enhanced, and high junctional straightness and tension are restored. These two mechanisms control junctional length and integrity during morphogenesis.
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