Journal
DEVELOPMENTAL CELL
Volume 47, Issue 4, Pages 479-+Publisher
CELL PRESS
DOI: 10.1016/j.devcel.2018.10.024
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Funding
- G. Harold and Leila Y. Mathers foundation
- NIH MIRA [GM118084]
- Deutsche Forschungsgemeinschaft
- Yale Center for Cellular and Molecular Imaging Facility (CCMI, NIH) [S10OD020142]
- NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES [P30DK045735] Funding Source: NIH RePORTER
- NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES [R35GM118084, R01GM118486] Funding Source: NIH RePORTER
- OFFICE OF THE DIRECTOR, NATIONAL INSTITUTES OF HEALTH [S10OD020142] Funding Source: NIH RePORTER
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While retrograde cargo selection in the Golgi is known to depend on specific signals, it is unknown whether anterograde cargo is sorted, and antero-grade signals have not been identified. We suggest here that S-palmitoylation of anterograde cargo at the Golgi membrane interface is an anterograde signal and that it results in concentration in curved regions at the Golgi rims by simple physical chemistry. The rate of transport across the Golgi of two S-palmitoylated membrane proteins is controlled by 5-palmitoylation. The bulk of 5-palmitoylated pro-teins in the Golgi behave analogously, as revealed by click chemistry-based fluorescence and electron microscopy. These palmitoylated cargos concen-trate in the most highly curved regions of the Golgi membranes, including the fenestrated perimeters of cisternae and associated vesicles. A palmitoylated transmembrane domain behaves similarly in model systems.
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