Journal
CURRENT TOPICS IN MEDICINAL CHEMISTRY
Volume 18, Issue 28, Pages 2420-2428Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1568026619666181210152115
Keywords
Histone Deacetylase; Inhibitors; Epigenetics; Cancer treatment; RNA; DNA
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Funding
- Natural Science Foundation of China [NSFC-81702476]
- Zhenzhou University [F0001140]
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Histone deacetylases (HDACs), as epigenetic modifiers, are essential for gene transcriptional activities. The alternation of HDACs expression, mutation and/or inappropriate recruitments has been discovered in a broad range of tumors contributing to the tumorigenesis through a serial of biological pathways. HDACs, therefore, are characterized as promising cancer therapeutic targets, and their inhibitors are under rapid development. Here, we discuss HDAC inhibitors in terms of their functional mechanism establishing the anti-tumor effects and potential clinical applications including the synergistic effects in combinational treatment.
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