Journal
CURRENT PHARMACEUTICAL DESIGN
Volume 24, Issue 42, Pages 4957-4978Publisher
BENTHAM SCIENCE PUBL LTD
DOI: 10.2174/1381612825666181206124206
Keywords
3D-printing; drop-on-solid; pressure-assisted microsyringe; fused filament fabrication; stereolithography; selective laser sintering; drug release control; individualized medicine
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Background: In the last decades, 3D-printing has been investigated and used intensively in the field of tissue engineering, automotive and aerospace. With the first FDA approved printed medicinal product in 2015, the research on 3D-printing for pharmaceutical application has attracted the attention of pharmaceutical scientists. Due to its potential of fabricating complex structures and geometrics, it is a highly promising technology for manufacturing individualized dosage forms. In addition, it enables the fabrication of dosage forms with tailored drug release profiles. Objective: The aim of this review article is to give a comprehensive overview of the used 3D-printing techniques for pharmaceutical applications, including information about the required material, advantages and disadvantages of the respective technique. Methods: For the literature research, relevant keywords were identified and the literature was then thoroughly researched. Conclusion: The current status of 3D-printing as a manufacturing process for pharmaceutical dosage forms was highlighted in this review article. Moreover, this article presents a critical evaluation of 3D-printing to control the dose and drug release of printed dosage forms.
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